• Corpus ID: 212574906

FORMULATION AND EVALUATION OF ANTIDIABETIC CAPSULES OF KAEMPFEROL-3- O-Β-D-6''-(P-COUMAROYL) GLUCOPYRANOSIDE EXTRACTED FROM ALLIUM CEPA L

@inproceedings{Ogbonna2019FORMULATIONAE,
  title={FORMULATION AND EVALUATION OF ANTIDIABETIC CAPSULES OF KAEMPFEROL-3- O-Β-D-6''-(P-COUMAROYL) GLUCOPYRANOSIDE EXTRACTED FROM ALLIUM CEPA L},
  author={Josephat Ikechukwu Ogbonna and O. N. C. Umeh and Chukwuemeka C. Mbah and Ben Chibuzo Amadi and Sabinus Ifeanyi Ofoefule and Benjamin Chukwuma Ozumba},
  year={2019}
}

• J. Ogbonna, O. Umeh, +3 authors B. Ozumba
• Published 2019

Allium cepa L. has known potent antidiabetic effects due to several of its constituents, including kaempferol -3-O-β-D-6''-(p-coumaroyl) glucopyranoside (kaempferol). This preliminary work was aimed at preparing oral hard gelatin capsules of kaempferol obtained from Allium cepa L. In order to obtain more potent hypoglycemic activities, lower side effects with good patient compliance over the crude extract kaempferol were isolated from Allium cepa L. and formulated into capsule dosage form. The capsules were prepared by filling hard gelatin capsule shells with blends of kaempferol with excipients which included Avicel PH102, agglomerated lactose, Primogel, Ac-Di-Sol, maize starch, stearic acid, and talc. The blends were evaluated for their micrometric properties such as bulk densities, tapped densities, Hausner’s quotients, compressibility indices, true densities, flow rate and angle of repose. Prepared capsules were evaluated for weight variation, disintegration time, content uniformity, dissolution profiles and antidiabetic properties in alloxan-induced diabetic rats with distilled water and glibenclamide respectively as negative and positive controls. The capsules were of good properties with disintegration time (2.75 ± 0.22 – 3.55 ± 0.55 min.). Drug release was within 92.12 – 99.57% within 30 min with faster drug release in batches containing Ac-DiSol and Primogel as disintegrants than those containing maize starch. Alloxanized diabetic rats attained normoglycemia within 2 weeks of continued daily administration of the capsule. Blood glucose reduction of 65.69 – 75.56% was attained within 3 weeks of continued daily administration of the drug. Kaempferol capsule dosage forms were effective in reducing blood sugar levels in alloxaninduced experimental diabetic rats. INTRODUCTION: Diabetes mellitus is a disease of disorder in the metabolism of carbohydrates, proteins and fats as a result of lack, inadequate secretion and or decreased action of insulin 1 .