FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise.

@article{Huh2012FNDC5AI,
  title={FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise.},
  author={Joo Young Huh and Grigorios Panagiotou and Vassilis G Mougios and Mary T Brinkoetter and Maria T Vamvini and Benjamin E. Schneider and Christos Socrates Mantzoros},
  journal={Metabolism: clinical and experimental},
  year={2012},
  volume={61 12},
  pages={1725-38}
}
OBJECTIVE In mouse, PGC1-α overexpression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. One prior study has shown that FNDC5 induces browning of subcutaneous fat in mice and mediates beneficial effects of exercise on metabolism, but a more recent study using gene expression arrays failed to detect a robust increase in FNDC5 mRNA in human muscles from exercising subjects. No prior study has reported… CONTINUE READING
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