FMRP involvement in formation of synapses among cultured hippocampal neurons.

  title={FMRP involvement in formation of synapses among cultured hippocampal neurons.},
  author={Katharina Braun and Menahem Segal},
  journal={Cerebral cortex},
  volume={10 10},
Fragile-X, the main cause of inherited human mental retardation is associated with the absence of a recently identified fragile-X mental retardation protein (FMRP). Mice in which this protein is lacking due to a knockout (KO) mutation are reported to express altered dendritic spines on their cortical neurons compared with wild type (WT) controls. We have used tissue-cultured neurons to examine differences in morphology and synaptic connectivity between WT and FMRP-deficient mice. Hippocampal… CONTINUE READING
81 Citations
38 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 81 extracted citations


Publications referenced by this paper.
Showing 1-10 of 38 references

Dendritic spine induction

  • M Segal, E Korkotian, DD Murphy
  • 2000
2 Excerpts

Neuroanatomy of the fragile X knockout mouse brain studied using in vivo high resolution magnetic resonance imaging

  • CE Bakker, RD Verheij, +10 authors A VanDerLinden
  • Eur J Hum Genet
  • 1999
1 Excerpt

Similar Papers

Loading similar papers…