FMR1 in global populations.

  title={FMR1 in global populations.},
  author={Catherine B. Kunst and C Zerylnick and L Karickhoff and Evan E. Eichler and James Bullard and Maryse Chalifoux and J. A. Holden and Antonio Torroni and David L. G. Nelson and Stephen T Warren},
  journal={American journal of human genetics},
  volume={58 3},
Fragile X syndrome, a frequent form of inherited mental retardation, results from the unstable expansion of a cryptic CGG repeat within the 5' UTR region of the FMR1 gene. The CGG repeat is normally polymorphic in length, and the content is frequently interrupted by AGG triplets. These interruptions are believed to stabilize the repeat, and their absence, leading to long tracts of perfect CGG repeats, may give rise to predisposed alleles. In order to examine the stability of normal FMR1 alleles… CONTINUE READING
24 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…