FMLP causes eicosanoid-dependent vasoconstriction and edema in lungs from endotoxin-primed rats.

@article{Voelkel1992FMLPCE,
  title={FMLP causes eicosanoid-dependent vasoconstriction and edema in lungs from endotoxin-primed rats.},
  author={Norbert Felix Voelkel and J Czartolomna and James Simpson and Robert C. Murphy},
  journal={The American review of respiratory disease},
  year={1992},
  volume={145 3},
  pages={701-11}
}
Recruitment of inflammatory cells to the lung capillaries has been proposed as an important step in the sequence of events that lead to acute lung injury. Frequently, in the clinical setting, bacteremia and sepsis syndrome precede the acute lung failure and endotoxin priming may represent a comparable paradigm, useful for experimental pursuit. Following addition of the chemotactic tripeptide FMLP (10(-9) to 10(-6) M) to the cell-free, salt solution perfusate of isolated rat lungs, only a small… CONTINUE READING