FM19G11 favors spinal cord injury regeneration and stem cell self-renewal by mitochondrial uncoupling and glucose metabolism induction.

@article{RodrguezJimnez2012FM19G11FS,
  title={FM19G11 favors spinal cord injury regeneration and stem cell self-renewal by mitochondrial uncoupling and glucose metabolism induction.},
  author={Francisco Javier Rodr{\'i}guez-Jimnez and Ana Alastrue-Agudo and Slaven Erceg and Miodrag Stojkovi{\'c} and Victoria Moreno-Manzano},
  journal={Stem cells},
  year={2012},
  volume={30 10},
  pages={2221-33}
}
Spinal cord injury is a major cause of paralysis with no currently effective therapies. Induction of self-renewal and proliferation of endogenous regenerative machinery with noninvasive and nontoxic therapies could constitute a real hope and an alternative to cell transplantation for spinal cord injury patients. We previously showed that FM19G11 promotes differentiation of adult spinal cord-derived ependymal stem cells under hypoxia. Interestingly, FM19G11 induces self-renewal of these… CONTINUE READING

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