FLUID PHASE DESTRUCTION OF C2hu BY C1hu

@article{Gigli1969FLUIDPD,
  title={FLUID PHASE DESTRUCTION OF C2hu BY C1hu },
  author={Irma Gigli and K Frank Austen},
  journal={The Journal of Experimental Medicine},
  year={1969},
  volume={130},
  pages={833 - 846}
}
It has been demonstrated that C1 isolated in the unactivated form fails to inactivate C4 or C2 in the fluid phase, while the activated molecule, C1 rapidly converts C4 to hemolytically inactive C4i, but does not efficiently inactivate C2. The production and presence of C4i now confers on C1 the ability to rapidly inactivate C2. After heating at 56 degrees C, so as to destroy the hemolytic activity, heat inactivated C1 is still capable of inactivating C4 but the presence of C4i no longer confers… CONTINUE READING

2 Figures & Tables