FLT3 mutations: biology and treatment.

@article{Small2006FLT3MB,
  title={FLT3 mutations: biology and treatment.},
  author={Donald M. Small},
  journal={Hematology. American Society of Hematology. Education Program},
  year={2006},
  pages={
          178-84
        }
}
  • Donald M. Small
  • Published in
    Hematology. American Society…
    2006
  • Medicine
  • FLT3 is a receptor tyrosine kinase with important roles in hematopoietic stem/progenitor cell survival and proliferation. It is mutated in about 1/3 of acute myeloid leukemia (AML) patients, either by internal tandem duplications (ITD) of the juxtamembrane domain or by point mutations usually involving the kinase domain (KD). Both types of mutation constitutively activate FLT3. Many studies have shown that AML patients with FLT3/ITD mutations have poor cure rates due to relapse. This has led to… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 145 CITATIONS, ESTIMATED 68% COVERAGE

    Genomics of Acute Myeloid Leukemia

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Liquid chromatography-tandem mass spectrometric assay for the quantitative determination of the tyrosine kinase inhibitor quizartinib in mouse plasma using salting-out liquid-liquid extraction.

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    FLT3-ITD Mutations in Acute Myeloid Leukemia Patients in Northeast Thailand.

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    FLT3 mutations in canine acute lymphocytic leukemia

    VIEW 6 EXCERPTS
    CITES BACKGROUND & RESULTS
    HIGHLY INFLUENCED

    Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    FILTER CITATIONS BY YEAR

    2007
    2020

    CITATION STATISTICS

    • 10 Highly Influenced Citations

    • Averaged 11 Citations per year from 2017 through 2019

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 43 REFERENCES

    FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells.

    VIEW 8 EXCERPTS
    HIGHLY INFLUENTIAL

    In vivo overexpression of Flt3 ligand expands and activates murine spleen natural killer dendritic cells.

    VIEW 1 EXCERPT

    FLT3 Tyrosine Kinase Inhibitors

    VIEW 1 EXCERPT