FLT3 internal tandem duplication in childhood acute myeloid leukaemia: association with hyperleucocytosis in acute promyelocytic leukaemia.

@article{Arrigoni2003FLT3IT,
  title={FLT3 internal tandem duplication in childhood acute myeloid leukaemia: association with hyperleucocytosis in acute promyelocytic leukaemia.},
  author={Paolo Arrigoni and Chiara Beretta and Daniela Malinverni Silvestri and V. Dal Pozzo Rossi and Carmelo Rizzari and Maria Grazia Valsecchi and Giovanni Cazzaniga and Andrea Biondi},
  journal={British journal of haematology},
  year={2003},
  volume={120 1},
  pages={89-92}
}
We evaluated the incidence of FLT3/internal tandem duplication (ITD) mutation in childhood acute myeloid leukaemia (AML) diagnosed over 15 years. FLT3/ITD was found in 10 of 45 (22.2%) non-acute promyelocytic leukaemia (non-APL) patients. The 5-year event-free survival of non-APL patients was higher in FLT3/ITD-negative versus -positive patients (48.9%, SE 8.9, vs 20.0%, SE 16.1, P = 0.03). In childhood APL, FLT3/ITD incidence was higher than in non-APL, although not statistically significant… CONTINUE READING

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