FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistance.

@article{Zwaan2003FLT3IT,
  title={FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistance.},
  author={Christian Michel Zwaan and Soheil Meshinchi and Jerald P Radich and Anjo J. P. Veerman and Dieuwke R. Huismans and Leonhard Munske and Martina Podleschny and Karel H{\"a}hlen and Rob Pieters and Martin Zimmermann and Dirk Reinhardt and Jochen Harbott and Ursula Creutzig and Gertjan J L Kaspers and Frank Griesinger},
  journal={Blood},
  year={2003},
  volume={102 7},
  pages={2387-94}
}
FLT3 is a receptor tyrosine kinase involved in the proliferation and differentiation of hematopoietic stem cells. FLT3 internal tandem duplications (FLT3/ITDs) are reported in acute myeloid leukemia (AML) and predict poor clinical outcome. We found FLT3/ITDs in 11.5% of 234 children with de novo AML. FLT3/ITD-positive patients were significantly older and had higher percentages of normal cytogenetic findings or French-American-British (FAB) classification M1/M2 and lower percentages of 11q23… CONTINUE READING

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