FLT3 and NPM1 mutations in Chinese patients with acute myeloid leukemia and normal cytogenetics

@article{Wang2010FLT3AN,
  title={FLT3 and NPM1 mutations in Chinese patients with acute myeloid leukemia and normal cytogenetics},
  author={Lei Wang and Wei-lai Xu and Hai-tao Meng and Wen-bin Qian and Wen-yuan Mai and Hongyan Tong and Li-ping Mao and Yin Tong and Jie-jing Qian and Yin-jun Lou and Zhi-mei Chen and Yun-gui Wang and Jie Jin},
  journal={Journal of Zhejiang University SCIENCE B},
  year={2010},
  volume={11},
  pages={762-770}
}
Mutations of fms-like tyrosine kinase 3 (FLT3) and nucleophosmin (NPM1) exon 12 genes are the most common abnormalities in adult acute myeloid leukemia (AML) with normal cytogenetics. To assess the prognostic impact of the two gene mutations in Chinese AML patients, we used multiplex polymerase chain reaction (PCR) and capillary electrophoresis to screen 76 AML patients with normal cytogenetics for mutations in FLT3 internal tandem duplication (FLT3/ITD) and exon 12 of the NPM1 gene. FLT3/ITD… CONTINUE READING