FLT3 and MLL intragenic abnormalities in AML reflect a common category of genotoxic stress.

@article{Libura2003FLT3AM,
  title={FLT3 and MLL intragenic abnormalities in AML reflect a common category of genotoxic stress.},
  author={Marta Libura and Vahid Asnafi and Angela Tu and Eric C M Delabesse and Isabelle Tigaud and Florence Cymbalista and Annelise Bennaceur-Griscelli and Patrick Villar{\`e}se and Gabriel Solbu and Anne M. Hagemeijer and Kheira Beldjord and Olivier Hermine and Elizabeth A Macintyre},
  journal={Blood},
  year={2003},
  volume={102 6},
  pages={2198-204}
}
MLL rearrangements in acute myeloid leukemia (AML) include translocations and intragenic abnormalities such as internal duplication and breakage induced by topoisomerase II inhibitors. In adult AML, FLT3 internal tandem duplications (ITDs) are more common in cases with MLL intragenic abnormalities (33%) than those with MLL translocation (8%). Mutation/deletion involving FLT3 D835 are found in more than 20% of cases with MLL intragenic abnormalities compared with 10% of AML with MLL… CONTINUE READING

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