FLT3-ITD positive acute myeloid leukemia: A retrospective analysis of the role of allogeneic transplant and allelic ratio in patient management.

@article{Taylor2018FLT3ITDPA,
  title={FLT3-ITD positive acute myeloid leukemia: A retrospective analysis of the role of allogeneic transplant and allelic ratio in patient management.},
  author={Emma Taylor and Kirk L Morris and Marc Ellis and P Marlton and Ketan Baveshi and Joseph Clarey and Ian M Irving and Tara Cochrane and Glen A. Kennedy},
  journal={Asia-Pacific journal of clinical oncology},
  year={2018}
}
AIM FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) positive AML is associated with increased relapse risk and reduced overall survival (OS) compared to non-FLT3-mutated AML. The aim of this study was to evaluate the impact of allelic ratio and allogeneic transplant on outcomes in FLT3-ITD+ AML. METHODS A retrospective study across five centers in Queensland, Australia, was conducted to examine survival outcomes and impact of FLT3-ITD allelic ratio and allograft. RESULTS… CONTINUE READING