FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model.

@article{Grundler2005FLT3ITDAT,
  title={FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model.},
  author={Rebekka Grundler and Cornelius Miething and Christian Thiede and Christian Peschel and Justus Duyster},
  journal={Blood},
  year={2005},
  volume={105 12},
  pages={4792-9}
}
Activating mutations of the Fms-like tyrosine kinase 3 (FLT3) receptor are the most common genetic alteration in acute myeloid leukemia (AML). Two distinct groups of FLT3 mutations are found: internal tandem duplications (ITDs) of the juxtamembrane region and point mutations within the tyrosine kinase domain (TKD). Recently, point mutations within the activation loop of FLT3 have also been described in childhood acute lymphoblastic leukemia (ALL). FLT3-ITD has been shown to induce a… CONTINUE READING

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Identification of novel 4798

  • FM Abu-Duhier, AC Goodeve, GA Wilson, RS Care, IR Peake, JT. Reilly
  • GRUNDLER et al BLOOD,
  • 2005

Point mutations of the FLT3-receptor tyrosine kinase in patients with acute myeloid leukemia: results of an intergroup analysis of the AML CG Study and the AML96 Study of the SHG [abstract

  • C Thiede, S Schnittger, W Kern
  • Blood
  • 2003

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