FLRT Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development

@inproceedings{Seiradake2014FLRTSB,
  title={FLRT Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development},
  author={Elena Seiradake and Daniel del Toro and Daniel Nagel and Florian Cop and Ricarda H{\"a}rtl and Tobias Ruff and Goenuel Seyit-Bremer and Karl Harlos and Ellen Clare Border and Amparo Acker-Palmer and E Yvonne Jones and Ruediger Klein},
  booktitle={Neuron},
  year={2014}
}
FLRTs are broadly expressed proteins with the unique property of acting as homophilic cell adhesion molecules and as heterophilic repulsive ligands of Unc5/Netrin receptors. How these functions direct cell behavior and the molecular mechanisms involved remain largely unclear. Here we use X-ray crystallography to reveal the distinct structural bases for FLRT-mediated cell adhesion and repulsion in neurons. We apply this knowledge to elucidate FLRT functions during cortical development. We show… CONTINUE READING
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