FLO1 Is a Variable Green Beard Gene that Drives Biofilm-like Cooperation in Budding Yeast

  title={FLO1 Is a Variable Green Beard Gene that Drives Biofilm-like Cooperation in Budding Yeast},
  author={Scott M Smukalla and Marina Caldara and Nathalie Pochet and Anne Beauvais and St{\'e}phanie Guadagnini and Chen Yan and Marcelo D. Vinces and An Jansen and Marie Christine Pr{\'e}vost and J. P. Latg{\'e} and Gerald Fink and Kevin R. Foster and Kevin J Verstrepen},
The budding yeast, Saccharomyces cerevisiae, has emerged as an archetype of eukaryotic cell biology. Here we show that S. cerevisiae is also a model for the evolution of cooperative behavior by revisiting flocculation, a self-adherence phenotype lacking in most laboratory strains. Expression of the gene FLO1 in the laboratory strain S288C restores flocculation, an altered physiological state, reminiscent of bacterial biofilms. Flocculation protects the FLO1 expressing cells from multiple… CONTINUE READING
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