FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal

@article{Dijkers2002FKHRL1CA,
  title={FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal},
  author={P F Dijkers and Kim U. Birkenkamp and Eric W-F Lam and Nicholas S. B. Thomas and Jan-Willem J Lammers and Leo Koenderman and Paul James Coffer},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={156},
  pages={531 - 542}
}
Survival signals elicited by cytokines include the activation of phosphatidylinositol 3-kinase (PI3K), which in turn promotes the activation of protein kinase B (PKB). Recently, PKB has been demonstrated to phosphorylate and inactivate forkhead transcription factor FKHR-L1, a potent inducer of apoptosis. To explore the mechanisms underlying the induction of apoptosis after cytokine withdrawal or FKHR-L1 activation, we used a cell line in which FKHR-L1 activity could be specifically induced… CONTINUE READING