FKBPs in chromatin modification and cancer.

  title={FKBPs in chromatin modification and cancer.},
  author={Y C Yao and Ya-Chen Liang and Huai-Huei Huang and W M Yang},
  journal={Current opinion in pharmacology},
  volume={11 4},
FK506-binding proteins (FKBPs) are intracellular receptors for FK506 and rapamycin, immunosuppressants that have recently been utilized as anticancer drugs. In the cytoplasm, FKBPs and these drugs modulate signal transduction pathways. However, recent reports reveal novel functions of FKBPs in the nucleus, which include regulation of transcription factors, histone chaperone activity, and modifications of chromatin structure. These activities are known to affect gene expression, DNA repair, and… CONTINUE READING

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