FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor.

@article{Jarczowski2009FKBP36IA,
  title={FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor.},
  author={Franziska Jarczowski and G{\"u}nther Jahreis and Frank Erdmann and Angelika Schierhorn and Gunter Fischer and Frank Edlich},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 2},
  pages={766-73}
}
FKBP36 has been previously shown to be a crucial factor in spermatogenesis because of its interplay with the synaptonemal complex protein SCPI. Here we show that beyond this function, FKBP36 forms complexes with glyceraldehyde-3-phosphate dehydrogenase (GAPDH; EC 1.2.1.12) and Hsp90. Both proteins bind independently to different sites of the FKBP36 tetratricopeptide repeat domain. The interaction between FKBP36 and GAPDH directly inhibits the catalytic activity of GAPDH. In addition, FKBP36… CONTINUE READING
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