FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines

Abstract

One of the pathological hallmarks of Alzheimer’s disease is the presence of insoluble extracellular amyloid plaques. These plaques are mainly constituted of amyloid beta peptide (Aβ), a proteolytic product of amyloid precursor protein (APP). APP processing also generates the APP intracellular domain (AICD). We have previously demonstrated that AICD… (More)
DOI: 10.1007/s12038-013-9400-1

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@article{Liu2013FKBP12RT, title={FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines}, author={Fan-Lun Liu and Ting-Yi Liu and Fan-Lu Kung}, journal={Journal of Biosciences}, year={2013}, volume={39}, pages={85-95} }