FKBP12 binds to acylated H-ras and promotes depalmitoylation.

@article{Ahearn2011FKBP12BT,
  title={FKBP12 binds to acylated H-ras and promotes depalmitoylation.},
  author={Ian Ahearn and Frederick D Tsai and Helen Court and Mo Zhou and Benjamin C. Jennings and M Ahmed and Nicole Fehrenbacher and Maurine E. Linder and Mark R Philips},
  journal={Molecular cell},
  year={2011},
  volume={41 2},
  pages={
          173-85
        }
}
A cycle of palmitoylation/depalmitoylation of H-Ras mediates bidirectional trafficking between the Golgi apparatus and the plasma membrane, but nothing is known about how this cycle is regulated. We show that the prolyl isomerase (PI) FKBP12 binds to H-Ras in a palmitoylation-dependent fashion and promotes depalmitoylation. A variety of inhibitors of the PI activity of FKBP12, including FK506, rapamycin, and cycloheximide, increase steady-state palmitoylation. FK506 inhibits retrograde… CONTINUE READING
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