FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease.

@article{Perren2015FK506RN,
  title={FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease.},
  author={Anke Van der Perren and Francesca Macchi and Jaan Toelen and Marianne S Carlon and M. P. F. H. L. van Maris and Henriette de Loor and Dirk Kuypers and Rik Gijsbers and Chris Van den Haute and Zeger Debyser and Veerle Baekelandt},
  journal={Neurobiology of aging},
  year={2015},
  volume={36 3},
  pages={1559-68}
}
Alpha-synuclein (α-synuclein) is considered a key player in Parkinson's disease (PD), but the exact relationship between α-synuclein aggregation and dopaminergic neurodegeneration remains unresolved. There is increasing evidence that neuroinflammatory processes are closely linked to dopaminergic cell death, but whether the inflammatory process is causally involved in PD or rather reflects secondary consequences of nigrostriatal pathway injury is still under debate. We evaluated the therapeutic… CONTINUE READING
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