FK506 is superior to methotrexate in therapeutic effects on advanced stage of rat adjuvant-induced arthritis

@article{Sakuma2001FK506IS,
  title={FK506 is superior to methotrexate in therapeutic effects on advanced stage of rat adjuvant-induced arthritis},
  author={S. Sakuma and F. Nishigaki and K. Magari and T. Ogawa and Susumu Miyata and Y. Ohkubo and T. Goto},
  journal={Inflammation Research},
  year={2001},
  volume={50},
  pages={509-514}
}
  • S. Sakuma, F. Nishigaki, +4 authors T. Goto
  • Published 2001
  • Medicine
  • Inflammation Research
  • Abstract.Objective and design: The anti-arthritic properties of FK506 were compared with methotrexate (MTX) in established adjuvant-induced arthritis (AIA) in rats.¶Material: Female Lewis rats.¶Treatment: Arthritic rats were orally administered with FK506 (1-5.6 mg/kg) and MTX (0.1-1 mg/kg) from days 15-24.¶Methods: Arthritis was induced by injection of Mycobacterium tuberculosis into the right hind footpad on day 0. Efficacy was determined on the basis of paw inflammation measured by paw… CONTINUE READING

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