FK506-induced neurotoxicity in liver transplantation.

  title={FK506-induced neurotoxicity in liver transplantation.},
  author={Eelco F. M. Wijdicks and Russell H. Wiesner and L J Dahlke and Ruud A F Krom},
  journal={Annals of neurology},
  volume={35 4},
We report FK506-induced neurotoxicity in 14 of 44 consecutive patients following orthoptic liver transplantation. In 10 of these 14 patients, postural hand tremors were found in the first weeks following surgery, transient apraxia of speech in 3, and generalized tonic-clonic seizures were noted in 2 patients. Other manifestations included nightmares, agitation, and acute delirium. Reduction of the FK506 dose resulted in resolution of symptoms, but in 1 patient mild speech difficulties and in 3… CONTINUE READING


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