FK506 enhances regeneration of axons across long peripheral nerve gaps repaired with collagen guides seeded with allogeneic Schwann cells.

@article{Udina2004FK506ER,
  title={FK506 enhances regeneration of axons across long peripheral nerve gaps repaired with collagen guides seeded with allogeneic Schwann cells.},
  author={Esther Udina and Francisco J. Rodrı́guez and Enrique Verd{\'u} and M{\'o}nica Espejo and Bruce G. Gold and Xavier Navarro},
  journal={Glia},
  year={2004},
  volume={47 2},
  pages={
          120-9
        }
}
We assessed the effects of FK506 administration on regeneration after a 6-mm gap repair with a collagen guide seeded with allogeneic Schwann cells (SCs) in the mouse sciatic nerve. SCs were isolated from predegenerated adult sciatic nerves and expanded in culture using a defined medium, before being seeded in the collagen guide embedded in Matrigel. Functional reinnervation was evaluated by noninvasive methods to determine recovery of motor, sensory, and autonomic functions in the hindpaw over… CONTINUE READING

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