FK506-binding protein of Neurospora crassa (NcFKBP) mediates sensitivity to the immunosuppressant FK506; resistant mutants identify two loci

@article{Barthelmess1993FK506bindingPO,
  title={FK506-binding protein of Neurospora crassa (NcFKBP) mediates sensitivity to the immunosuppressant FK506; resistant mutants identify two loci},
  author={Ilse Babette Barthelmess and M. Tropschug},
  journal={Current Genetics},
  year={1993},
  volume={23},
  pages={54-58}
}
Growth of Neurospora crassa wild-type is inhibited by micromolar concentrations of the immuno-suppressive macrolide FK506. Spontaneous and induced mutations that confer resistance to FK506 identified two loci, fkr-1 and fkr-2. They map on the right arm of linkage group V on either side of inl with fkr-1 being centromere proximal. Allele fb (fkr-2) lacks immunodetectable N. crassa FK506-binding protein (NcFKBP). This demonstrates that the sensitivity of N. crassa towards FK506 is mediated by… CONTINUE READING

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