FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway.

Abstract

FK506 binding protein 5 (FKBP5) belongs to a family of immunophilins named for their ability to bind immunosuppressive drugs, also known as peptidyl-prolyl cis-trans isomerases, and also with chaperones to help protein folding. Using glioma cDNA microarray analysis, we found that FKBP5 was overexpressed in glioma tumors. This finding was further validated… (More)

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Cite this paper

@article{Ban2008FK506BP, title={FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway.}, author={Xinxin Ban and Simona Cazacu and Cunli Xiang and Jean Claude Zenklusen and Howard A. Fine and Michael Berens and Brock A Armstrong and Chaya Brodie and Tom Mikkelsen}, journal={Neoplasia}, year={2008}, volume={10 3}, pages={235-43} }