FK506 and anti-CD40 ligand in peripheral nerve allotransplantation.


PURPOSE Immunomodulatory agents are often combined in organ transplantation to minimize toxicity and enhance therapeutic effect. We hypothesized that combining low-dose FK506 with anti-CD40 Ligand (anti-CD40L mAb) would enhance regeneration through peripheral nerve allografts while preserving immune unresponsiveness. METHODS Eighty Balb/cJ mice underwent… (More)