FK506 "rescue" for resistant rejection of renal allografts under primary cyclosporine immunosuppression.

  title={FK506 "rescue" for resistant rejection of renal allografts under primary cyclosporine immunosuppression.},
  author={Mark L. Jordan and Ron L Shapiro and Carlos A Vivas and Velma P. Scantlebury and P Rhandhawa and G Carrieri and Jerry McCauley and Anthony Jack Demetris and Andreas Tzakis and John J. Fung},
  volume={57 6},
Seventy-seven patients with ongoing acute rejection on initial CsA therapy were converted to FK506 to attempt graft salvage. Fifty-nine patients had undergone primary transplantation and 18 had been retransplanted; there were 52 cadaveric and 25 living-donor transplants. The indications for conversion to FK506 were ongoing, biopsy-confirmed rejection in all patients, including vascular rejection in 20. The median interval to rescue was 2 months (range 2 weeks to 36 months) after transplantation… CONTINUE READING


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