FK 506 alleviates blood-retinal barrier breakdown and reduces retinal vascular permeability in early streptozotocin-induced diabetic rat

@inproceedings{Zhang2017FK5A,
  title={FK 506 alleviates blood-retinal barrier breakdown and reduces retinal vascular permeability in early streptozotocin-induced diabetic rat},
  author={Wei Zhang and J Ma and Shuang-Nong Li},
  year={2017}
}
Objective: Diabetic retinopathy is a complex disease that potentially involves inflammation in its pathogenesis. It has been demonstrated that FK506, one of its potent immunosuppressive agents, possess anti-inflammatory properties. Therefore, the present study aimed to explore whether FK506 could reduce vascular damage in experimental diabetic retinopathy. Methods: The streptozotocin-induced model of diabetes was established using Wistar rats. Animals received single intravitreal injections of… CONTINUE READING
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