FIZZ1 plays a crucial role in early stage airway remodeling of OVA-induced asthma.

@article{Dong2008FIZZ1PA,
  title={FIZZ1 plays a crucial role in early stage airway remodeling of OVA-induced asthma.},
  author={Liang Dong and Shu-juan Wang and Blanca Camoretti-Mercado and Hong-jia Li and Ming Chen and Wen-xiang Bi},
  journal={The Journal of asthma : official journal of the Association for the Care of Asthma},
  year={2008},
  volume={45 8},
  pages={
          648-53
        }
}
The aim of this study was to elucidate the role of Found in Inflammatory Zone 1 (FIZZ1, also known as RELM-alpha or resistin-like molecule-alpha) in airway remodeling in asthma. We used a rat model of ovalbumin (OVA) sensitization and challenge to induce lung inflammation and remodeling. Expression of alpha -SMA in the lungs of OVA-treated rats was significantly elevated in the peribronchial regions compared with control saline-treated animals. Expression of FIZZ1 mRNA in alveolar epithelial… CONTINUE READING
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