FISH detection of HER-2/neu oncogene amplification in early onset breast cancer

@article{Xing1996FISHDO,
  title={FISH detection of HER-2/neu oncogene amplification in early onset breast cancer},
  author={W Xing and Kennedy W. Gilchrist and Charles P. Harris and Wilner Samson and Lorraine Faxon Meisner},
  journal={Breast Cancer Research and Treatment},
  year={1996},
  volume={39},
  pages={203-212}
}
HER-2/neu (c-erbB-2) gene amplification based on Southern blotting or immunohistochemistry has been shown to be predictive of poor outcome in breast cancer occurring in women over 40, but there is little data on the role of HER-2/neu in young women with breast cancer, many of whom may have inherited BRCA1 or other predisposing genes. The present study used fluorescent in situ hybridization (FISH) on archival specimens of breast cancer from 37 women under the age of 40 to evaluate the role of… CONTINUE READING