FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome

@article{Yoshimoto2007FISHAO,
  title={FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome},
  author={Masataka Yoshimoto and Isabela Werneck da Cunha and Renata de Almeida Coudry and Francisco Paulo da Fonseca and C{\'e}sar Henrique Torres and Fernando Augusto Soares and Jeremy A Squire},
  journal={British Journal of Cancer},
  year={2007},
  volume={97},
  pages={678 - 685}
}
This study examines the clinical impact of PTEN genomic deletions using fluorescence in situ hybridisation (FISH) analysis of 107 prostate cancers, with follow-up information covering a period of up to 10 years. Tissue microarray analysis using interphase FISH indicated that hemizygous PTEN losses were present in 42/107 (39%) of prostatic adenocarcinomas, with a homozygous PTEN deletion observed in 5/107 (5%) tumours. FISH analysis using closely linked probes centromeric and telomeric to the… CONTINUE READING

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