FISH Analysis of Gene Aberrations (MYC, CCND1, ERBB2, RB, and AR) in Advanced Prostatic Carcinomas Before and After Androgen Deprivation Therapy

@article{KaltzWittmer2000FISHAO,
  title={FISH Analysis of Gene Aberrations (MYC, CCND1, ERBB2, RB, and AR) in Advanced Prostatic Carcinomas Before and After Androgen Deprivation Therapy},
  author={Christine Kaltz-Wittmer and Ulrich Klenk and Axel Glaessgen and Daniela E. Aust and Joachim Diebold and Udo Loehrs and Gustavo Bruno Baretton},
  journal={Laboratory Investigation},
  year={2000},
  volume={80},
  pages={1455-1464}
}
Genetic mechanisms leading to androgen-independent growth in advanced prostatic carcinomas (PC) are still poorly understood. Analysis of genes potentially involved in the regulation of tumor cell proliferation and apoptosis might confer better insight into this process and might lead to improved therapeutic strategies. Fluorescence in situ hybridization (FISH) analysis of dissociated nuclei with DNA probes for MYC (8q24)/#8, cyclin D1 gene (CCND1; 11q13)/#11, ERBB2 (17q13)/#17, the androgen… CONTINUE READING

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