FIREWACh: High-throughput Functional Detection of Transcriptional Regulatory Modules in Mammalian Cells

@inproceedings{Murtha2014FIREWAChHF,
  title={FIREWACh: High-throughput Functional Detection of Transcriptional Regulatory Modules in Mammalian Cells},
  author={Matthew Murtha and Zeynep Tokcaer-Keskin and Zuojian Tang and Francesco Strino and Xi Chen and Yatong Wang and Xiangmei Xi and Claudio Basilico and Stuart M. Brown and Richard Bonneau and Yuval Kluger and Lisa A. Dailey},
  booktitle={Nature Methods},
  year={2014}
}
Promoters and enhancers establish precise gene transcription patterns. The development of functional approaches for their identification in mammalian cells has been complicated by the size of these genomes. Here we report a high-throughput functional assay for directly identifying active promoter and enhancer elements called FIREWACh (Functional Identification of Regulatory Elements Within Accessible Chromatin), which we used to simultaneously assess over 80,000 DNA fragments derived from… CONTINUE READING

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