FIP1L1-PDGFRA molecular analysis in the differential diagnosis of eosinophilia

  title={FIP1L1-PDGFRA molecular analysis in the differential diagnosis of eosinophilia},
  author={Gedeon Loules and Fani Kalala and Nikolaos C Giannakoulas and Emmanouil C Papadakis and Panagiota Matsouka and Matthaios Speletas},
  journal={BMC Blood Disorders},
  pages={1 - 1}
BACKGROUND Primary eosinophlia associated with the FIP1L1-PDGFRA rearrangement represents a subset of chronic eosinophilic leukaemia (CEL) and affected patients are very sensitive to imatinib treatment. This study was undertaken in order to examine the prevalence and the associated clinicopathologic and genetic features of FIP1L1-PDGFRA rearrangement in a cohort of 15 adult patients presenting with profound eosinophilia (> 1.5 x 109/L). METHODS Reverse transcriptase-polymerase chain reaction… CONTINUE READING
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