FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis

@article{Hattula2000FIP2AC,
  title={FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis},
  author={Katarina Hattula and J. Per{\"a}nen},
  journal={Current Biology},
  year={2000},
  volume={10},
  pages={1603-1606}
}
Huntington's disease is characterised by the death of cortical and striatal neurons, and is the result of an expanded polyglutamine tract in the Huntingtin protein [1]. Huntingtin is present on both endocytic and secretory membrane organelles but its function is unclear [2,3]. Rab GTPases regulate both of these transport pathways [4]. We have previously shown that Rab8 controls polarised membrane transport by modulating cell morphogenesis [5]. To understand Rab8-mediated processes, we searched… Expand
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Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane
Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease
Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin
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References

SHOWING 1-10 OF 18 REFERENCES
Huntingtin interacts with a family of WW domain proteins.
Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain.
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase.
Wild-Type and Mutant Huntingtins Function in Vesicle Trafficking in the Secretory and Endocytic Pathways
Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system.
Wild-Type Huntingtin Protects from Apoptosis Upstream of Caspase-3
Expression of Huntingtin-Associated Protein-1 in Neuronal Cells Implicates a Role in Neuritic Growth
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