FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.

@article{Okamoto2013FHL2PC,
  title={FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.},
  author={Ryuji Okamoto and Yuxin Li and Kensuke Noma and Yukio Hiroi and Ping-Yen Liu and Masaya Taniguchi and Masaaki Ito and James K. Liao},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2013},
  volume={27 4},
  pages={1439-49}
}
The Rho-associated coiled-coil containing kinases, ROCK1 and ROCK2, are important regulators of cell shape, migration, and proliferation through effects on the actin cytoskeleton. However, it is not known whether ROCK2 plays an important role in the development of cardiac hypertrophy. To determine whether the loss of ROCK2 could prevent cardiac hypertrophy, cardiomyocyte-specific ROCK2-null (c-ROCK2(-/-)) were generated using conditional ROCK2(flox/flox) mice and α-myosin heavy-chain promoter… CONTINUE READING

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