FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression.

@article{Hamidouche2008FHL2MD,
  title={FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression.},
  author={Zahia Hamidouche and Eric Ha{\"y} and Pascal Vaudin and Pierre Charbord and Roland Sch{\"u}le and Pierre Jacques Marie and Olivia Fromigu{\'e}},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2008},
  volume={22 11},
  pages={3813-22}
}
The differentiation of bone marrow mesenchymal stem cells (MSCs) into osteoblasts is a crucial step in bone formation. However, the mechanisms involved in the early stages of osteogenic differentiation are not well understood. In this study, we identified FHL2, a member of the LIM-only subclass of the LIM protein superfamily, that is up-regulated during early osteoblast differentiation induced by dexamethasone in murine and human MSCs. Gain-of-function studies showed that FHL2 promotes the… CONTINUE READING
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