FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development.

@article{Bei1998FGFsAB,
  title={FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development.},
  author={Marianna Bei and Richard L. Maas},
  journal={Development},
  year={1998},
  volume={125 21},
  pages={4325-33}
}
During early tooth development, multiple signaling molecules are expressed in the dental lamina epithelium and induce the dental mesenchyme. One signal, BMP4, has been shown to induce morphologic changes in dental mesenchyme and mesenchymal gene expression via Msx1, but BMP4 cannot substitute for all the inductive functions of the dental epithelium. To investigate the role of FGFs during early tooth development, we examined the expression of epithelial and mesenchymal Fgfs in wild-type and Msx1… CONTINUE READING