FGFs: crucial factors that regulate tumour initiation and progression.

  title={FGFs: crucial factors that regulate tumour initiation and progression.},
  author={Qian Jing and Yuanyuan Wang and Hao Liu and Xiaowei Deng and Lin Jiang and Rui Liu and Haixing Song and Jingyi Li},
  journal={Cell proliferation},
  volume={49 4},
Fibroblast growth factors (FGFs) are crucial signalling molecules involved in normal cell growth, differentiation and proliferation. Over the past few decades, a large body of research has illustrated effects of individual FGFs on tumour initiation and progression. Tumour development is commonly accompanied with generation of new blood and lymph vessels, which support enhanced cell proliferation. Moreover, acquisition of tumour cells of the epithelial-mesenchymal transition (EMT) phenotype… CONTINUE READING