FGFR4 transmembrane domain polymorphism and cancer risk: a meta-analysis including 8555 subjects.

@article{Xu2010FGFR4TD,
  title={FGFR4 transmembrane domain polymorphism and cancer risk: a meta-analysis including 8555 subjects.},
  author={Wei Xu and Yan Li and Xueli Wang and Bo Chen and Yanli Wang and Shifeng Liu and Jijun Xu and Weihong Zhao and Jianqing Wu},
  journal={European journal of cancer},
  year={2010},
  volume={46 18},
  pages={3332-8}
}
Fibroblast growth factor receptor 4 (FGFR4), belonging to the receptor tyrosine kinase family, is involved in cancer initiation and progression. The FGFR4 Gly388Arg polymorphism in the transmembrane domain of the receptor was shown to contribute to genetic susceptibility to cancer but the results were inconsistent. We performed a meta-analysis using 12 eligible case-control studies with a total of 4892 patients and 3663 controls to summarise the data on the association between the FGFR4… CONTINUE READING

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