FGFR3 regulates brain size by controlling progenitor cell proliferation and apoptosis during embryonic development.

@article{InglisBroadgate2005FGFR3RB,
  title={FGFR3 regulates brain size by controlling progenitor cell proliferation and apoptosis during embryonic development.},
  author={Suzanne L Inglis-Broadgate and Rachel E. Thomson and Francesca Pellicano and Michael A Tartaglia and Charlie C Pontikis and Jonathan D Cooper and Tomoko Iwata},
  journal={Developmental biology},
  year={2005},
  volume={279 1},
  pages={73-85}
}
Mice with the K644E kinase domain mutation in fibroblast growth factor receptor 3 (Fgfr3) (EIIa;Fgfr3(+/K644E)) exhibited a marked enlargement of the brain. The brain size was increased as early as E11.5, not secondary to the possible effect of Fgfr3 activity in the skeleton. Furthermore, the mutant brains showed a dramatic increase in cortical thickness, a phenotype opposite to that in FGF2 knockout mice. Despite this increased thickness, cortical layer formation was largely unaffected and no… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Neocortical arealization: evolution, mechanisms, and open questions.

Developmental neurobiology • 2013
View 4 Excerpts
Highly Influenced

Molecular investigations of development and diseases of the brain of higher mammals using the ferret

Proceedings of the Japan Academy. Series B, Physical and biological sciences • 2017

Similar Papers

Loading similar papers…