FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma

  title={FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma},
  author={Yuanyuan Shi and Xuejiao Liu and Mangaladoss Fredimoses and Mengqiu Song and Hanyong Chen and Kangdong Liu and Mee‐Hyun Lee and Zigang Dong},
  journal={Journal of Cellular Biochemistry},
  pages={2231 - 2239}
Fibroblast growth factor receptor (FGFR) 2 and its downstream signaling cascades, PI3 K/AKT/mTOR is playing an important role in cell survival and proliferations. In this study, we firstly found that picrasidine Q (PQ), an alkaloid component extracted from Angelica keiskei species, has the capacity of anti‐cell transformation and anti‐cancer. After ligand shape similarity approach of PQ, we found that PQ targeted FGFR 2 and verified by FGFR2 kinase assay as well as computational docking model… 
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  • D. Ornitz, N. Itoh
  • Biology
    Wiley interdisciplinary reviews. Developmental biology
  • 2015
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.