FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior

  title={FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior},
  author={Athina-Myrto Chioni and Richard Grose},
  booktitle={The Journal of cell biology},
FGF-10 and its receptors, FGFR1 and FGFR2, have been implicated in breast cancer susceptibility and progression, suggesting that fibroblast growth factor (FGF) signaling may be co-opted by breast cancer cells. We identify a novel pathway downstream of FGFR1 activation, whereby the receptor is cleaved and traffics to the nucleus, where it can regulate specific target genes. We confirm Granzyme B (GrB) as the protease responsible for cleavage and show that blocking GrB activity stopped FGFR1… CONTINUE READING
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Fibroblast growth factor receptor1 ( FGFR 1 ) nuclear dynamics reveal a novel mechanism in transcription control

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