FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior

@inproceedings{Chioni2012FGFR1CA,
  title={FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior},
  author={Athina-Myrto Chioni and Richard Grose},
  booktitle={The Journal of cell biology},
  year={2012}
}
FGF-10 and its receptors, FGFR1 and FGFR2, have been implicated in breast cancer susceptibility and progression, suggesting that fibroblast growth factor (FGF) signaling may be co-opted by breast cancer cells. We identify a novel pathway downstream of FGFR1 activation, whereby the receptor is cleaved and traffics to the nucleus, where it can regulate specific target genes. We confirm Granzyme B (GrB) as the protease responsible for cleavage and show that blocking GrB activity stopped FGFR1… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 23 references

Fibroblast growth factor receptor1 ( FGFR 1 ) nuclear dynamics reveal a novel mechanism in transcription control

  • M. J. Grainge, I. O. Ellis, J. S. Reis-Filho
  • Mol . Biol . Cell .
  • 2009

Negative regulation of fibroblast growth factor 10 ( FGF10 ) by polyoma enhancer activator 3 ( PEA 3 )

  • A. M. Chioni, G. P. Wilkin, J. K. Diss, M. B. Djamgoz
  • Eur . J . Cell Biol .
  • 2009

Similar Papers

Loading similar papers…