FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis

@article{Elsheikh2006FGFR1AI,
  title={FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis},
  author={Somaia Elbauomy Elsheikh and Andrew R. Green and Maryou B. K. Lambros and Nicholas C. Turner and Matthew J Grainge and Des Powe and Ian O. Ellis and Jorge S Reis-Filho},
  journal={Breast Cancer Research},
  year={2006},
  volume={9},
  pages={R23 - R23}
}
The amplicon on 8p11.2 is reported to be found in up to 10% of breast carcinomas. It has been demonstrated recently that this amplicon has four separate cores. The second core encompasses important oncogene candidates, including the fibroblast growth factor receptor 1 (FGFR1) gene. Recent studies have demonstrated that specific FGFR1 amplification correlates with gene expression and that FGFR1 activity is required for the survival of a FGFR1 amplified breast cancer cell line. FGFR1… CONTINUE READING
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