FGFR1-Induced Epithelial to Mesenchymal Transition through MAPK/PLCγ/COX-2-Mediated Mechanisms

@article{Tomlinson2012FGFR1InducedET,
  title={FGFR1-Induced Epithelial to Mesenchymal Transition through MAPK/PLC$\gamma$/COX-2-Mediated Mechanisms},
  author={D. Tomlinson and E. Baxter and P. Loadman and M. Hull and M. Knowles},
  journal={PLoS ONE},
  year={2012},
  volume={7}
}
Tumour invasion and metastasis is the most common cause of death from cancer. For epithelial cells to invade surrounding tissues and metastasise, an epithelial-mesenchymal transition (EMT) is required. We have demonstrated that FGFR1 expression is increased in bladder cancer and that activation of FGFR1 induces an EMT in urothelial carcinoma (UC) cell lines. Here, we created an in vitro FGFR1-inducible model of EMT, and used this model to identify regulators of urothelial EMT. FGFR1 activation… Expand
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