FGFR-TACC gene fusions in human glioma

  title={FGFR-TACC gene fusions in human glioma},
  author={A. Lasorella and M. Sanson and A. Iavarone},
  • A. Lasorella, M. Sanson, A. Iavarone
  • Published 2017
  • Biology, Medicine
  • Neuro-Oncology
  • Chromosomal translocations joining in-frame members of the fibroblast growth factor receptor-transforming acidic coiled-coil gene families (the FGFR-TACC gene fusions) were first discovered in human glioblastoma multiforme (GBM) and later in many other cancer types. Here, we review this rapidly expanding field of research and discuss the unique biological and clinical features conferred to isocitrate dehydrogenase wild-type glioma cells by FGFR-TACC fusions. FGFR-TACC fusions generate powerful… CONTINUE READING
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