FGF8 acts as a classic diffusible morphogen to pattern the neocortex

@article{Toyoda2010FGF8AA,
  title={FGF8 acts as a classic diffusible morphogen to pattern the neocortex},
  author={Reiko Toyoda and Stavroula Assimacopoulos and Jennifer Slone Wilcoxon and Albert Taylor and Polina Feldman and Asuka Suzuki-Hirano and Tomomi Shimogori and Elizabeth A Grove},
  journal={Development},
  year={2010},
  volume={137},
  pages={3439 - 3448}
}
Gain- and loss-of-function experiments have demonstrated that a source of fibroblast growth factor (FGF) 8 regulates anterior to posterior (A/P) patterning in the neocortical area map. Whether FGF8 controls patterning as a classic diffusible morphogen has not been directly tested. We report evidence that FGF8 diffuses through the mouse neocortical primordium from a discrete source in the anterior telencephalon, forms a protein gradient across the entire A/P extent of the primordium, and acts… Expand
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