FGF8 Acts as a Right Determinant during Establishment of the Left-Right Axis in the Rabbit

  title={FGF8 Acts as a Right Determinant during Establishment of the Left-Right Axis in the Rabbit},
  author={Anja Fischer and Christoph von Viebahn and Martin Blum},
  journal={Current Biology},
BACKGROUND FGF8 has been implicated in the transfer of left-right (L-R) asymmetry from the embryonic midline (node) to the lateral plate mesoderm (LPM). Surprisingly, opposite roles have been described in chick and mouse. In mouse, FGF8 is required for the left-asymmetric expression of nodal, lefty2, and Pitx2. In chick, FGF8 represses nodal and Pitx2 on the right side. This discrepancy could reflect evolutionary differences between birds and mammals. Alternatively, the right-asymmetric… CONTINUE READING
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